5-MeO-DMT (5-Methoxy-N, N-dimethyltryptamine) is a powerful psychedelic compound found in various plants and the secretions of the Colorado River toad (Bufo Alvarius). It is chemically similar to DMT (N, N-dimethyltryptamine) but has distinct effects and a shorter duration. 5-MeO-DMT is known for its intense, short-lived, and often transformative psychedelic experiences. It primarily acts as a serotonin receptor agonist.


The experience with 5-MeO-DMT is typically profound and short-lived, lasting around 15-20 minutes. Users often report a rapid onset of effects, a sensation of leaving their body or ego dissolution, and a merging with the universe or a sense of unity with all things. These experiences are often described as mystical, ego-obliterating, and transcendental, with users feeling a profound connection to the universe or a divine presence.


  • Profound ego dissolution and a loss of sense of self.
  • Intense, vivid, and often ineffable mystical or spiritual experiences.
  • A strong sense of unity with the universe or a divine presence.
  • Altered perceptions of time, space, and reality.
  • Emotional release and catharsis.
  • Enhanced sensory perception, including visual and auditory distortions.

How to

  • Smoking or Vaporizing: This is a common method of consumption. The substance is heated and the vapors are inhaled. This method tends to produce a rapid onset of effects.
  • Insufflation (Snorting): Some individuals consume 5-MeO-DMT by snorting the powdered form. This method can lead to a quicker onset of effects compared to oral ingestion but slower than smoking or vaporizing.
  • Oral Ingestion: 5-MeO-DMT may be taken orally, often combined with an MAOI (monoamine oxidase inhibitor) to make it orally active, as MAOIs prevent the breakdown of the substance in the digestive system.
  • Intravenous or Intramuscular Injection: This is a less common and more risky method, where the substance is injected directly into the bloodstream or muscle.

Can you mix it with other substances? Click here for a detailed chart of safe drug combinations.

Benefits & Risks

BenefitsSpiritual and Personal Insights: Many users report profound spiritual or personal insights, leading to increased self-awareness and personal growth.
Therapeutic Potential: 5-MeO-DMT is being explored for its therapeutic potential in treating conditions like depression, anxiety, and addiction.
Mystical Experiences: It can induce intense mystical experiences that some find meaningful and transformative.
RisksIntensity: The intensity of the experience can be overwhelming and potentially distressing.
Unpredictability: Individual responses vary, and it can be difficult to predict the exact nature of the experience.
Physical Risks: 5-MeO-DMT can lead to rapid heart rate and elevated blood pressure, which may pose risks for individuals with heart conditions.
Mental Health: It may exacerbate or trigger mental health issues in some individuals.

Therapeutic Use

5-MeO-DMT is being researched for its potential therapeutic applications, including the treatment of mental health disorders such as depression, anxiety, and addiction. Its ability to induce mystical experiences is of interest in psychotherapy and personal growth.

Personal Growth

Many users of 5-MeO-DMT report experiences that they consider highly meaningful and transformative. These experiences can lead to personal growth, increased self-awareness, and a shift in one’s perspective on life and the universe.


The legal status of 5-MeO-DMT varies by country and region. In some places, it is classified as a controlled substance, while in others, it may be unregulated or decriminalized. It’s essential to check the specific laws and regulations in your area.

History & Stats

5-MeO-DMT has a long history of use in indigenous shamanic practices, particularly in South America. It gained popularity in Western psychedelic culture during the mid-20th century. Statistics on its use are limited due to its relatively recent emergence in mainstream consciousness and its legal status.


  • Not LSD: 5-MeO-DMT is often confused with LSD, but they are entirely different substances with distinct effects.
  • Legal Status: Some people believe it is legal everywhere, which is not true; its legality varies worldwide.
  • Non-Psychoactive: Contrary to some myths, 5-MeO-DMT is a potent psychoactive compound with intense effects.
  • Safe for Everyone: Like all psychedelics, 5-MeO-DMT is not without risks, and its safety depends on individual factors and proper use. It should not be considered universally safe for all individuals.

It’s important to approach 5-MeO-DMT with caution and understand its effects and risks. Have you had an experience with 2C-B and need support to integrate it? Or do you plan on having one and want the best setting possible? Book a session with one of our coaches.