4-AcO-DMT, also known as O-Acetylpsilocin, is a synthetic psychoactive drug, often referred to as the “synthetic shroom”. It’s chemically similar to psilocybin, the active ingredient in psilocybin mushrooms (“magic mushrooms”). It belongs to a group known as the substituted tryptamines, which act on the serotonin receptors in the brain.


Users of 4-AcO-DMT report experiences similar to those of psilocybin, including altered perception of time and space, enhanced introspection, visual hallucinations, and profound changes in mood and thought. The intensity of these effects depends on the dosage and individual sensitivity.


PhysicalAltered sensory perception
Pupil dilation
Increased heart rate
Nausea and gastrointestinal discomfort
Altered motor skills
PsychologicalVisual and auditory hallucinations
Enhanced introspection
Altered perception of time and space
Emotional euphoria or dysphoria
Profound changes in mood and thought patterns
Sensation of spiritual or mystical experience

How to

  • Oral Ingestion: This is the most common method, involving swallowing pills, capsules, or powder. Effects usually start within 20 to 40 minutes and can last 4 to 7 hours.
  • Insufflation (Snorting): Involves snorting the powder form. This method leads to a quicker onset, often within 10 to 15 minutes, but might result in a shorter duration.
  • Sublingual Administration: Placing the substance under the tongue for absorption into the bloodstream. Onset typically occurs within 15 to 30 minutes, possibly offering a slightly different experience.
  • Injection (Intravenous or Intramuscular): Less common and riskier, this method involves injecting the substance directly into the bloodstream (IV) or muscle (IM), leading to an almost immediate onset of effects.
  • Vaporization/Smoking: A less common and less studied method, where the substance is vaporized or smoked. It might produce a rapid onset of effects with a shorter duration.

Can you mix it with other substances? Click here for a detailed chart of safe drug combinations.

Benefits & Risks

BenefitsSome users report relief from depression, anxiety, and PTSD symptoms, echoing the benefits observed in clinical studies of psilocybin.
Potential for facilitating profound introspective experiences that may lead to personal growth and improved mental health.
Reports of life-changing spiritual experiences and feelings of interconnectedness.
Some users find it useful for self-exploration and psychotherapeutic insights.
RisksPotential for nausea and vomiting.
The possible strain on the cardiovascular system.
Risk of physical accidents while under the influence.
Potential for inducing or exacerbating mental health issues like anxiety or psychosis, especially in predisposed individuals.
Risk of challenging or traumatic psychological experiences (“bad trips”).
Potential for psychological dependence in some users.

Therapeutic Use

Research into the therapeutic use of 4-AcO-DMT is limited. However, it is studied for potential benefits in treating depression, anxiety, and PTSD, similar to related compounds like psilocybin.

Personal Growth

Users often report experiences that contribute to personal growth, like increased empathy, emotional processing, and self-awareness. However, these experiences are highly subjective and vary greatly.


4-AcO-DMT is illegal in many countries. It often falls under the same legal category as other psychedelic substances, though the specific legal status can vary by region.

History & Stats

First synthesized in the late 20th century, 4-AcO-DMT was initially researched as a potential alternative to psilocybin for psychotherapeutic purposes. Its use outside of clinical settings has been largely recreational and experimental.

There is limited statistical data on the use of 4-AcO-DMT, as it is less common than other psychedelics like LSD or psilocybin. User reports and small-scale studies provide most of the current information.


Common myths include the belief that 4-AcO-DMT is completely safe because it is similar to psilocybin. While it shares many properties, the differences can be significant, especially in terms of potency and risk profile.

It’s important to approach 4-AcO-DMT with caution and understand its effects and risks. Have you had an experience with 4-AcO-DMT and need support to integrate it? Or do you plan on having one and want the best setting possible? Book a session with one of our coaches.