Mescaline is a naturally occurring psychedelic compound found in various cacti, such as the peyote cactus (Lophophora williamsii) and the San Pedro cactus (Echinopsis pachanoi). It has a long history of use in indigenous rituals and shamanic practices, as it induces altered states of consciousness and profound spiritual experiences. Mescaline is classified as a classic hallucinogen, known for its mind-altering effects.

Other given names to Mescaline:

  • 3,4,5-Trimethoxyphenethylamine
  • Mezcaline
  • Peyote
  • San Pedro
  • Buttons
  • Cactus
  • M
  • Moon


Mescaline experiences can vary significantly from person to person, but they generally involve visual and sensory distortions. Users often describe enhanced colours, patterns, and a heightened sense of interconnectedness with their surroundings. Hallucinations are common, including both closed-eye and open-eye visuals. Many people report a sense of euphoria, introspection, and a feeling of being in tune with nature and the universe during a mescaline trip.


The effects typically last for 8-12 hours, depending on the dosage and individual sensitivity. Some common effects include:

  • Visual hallucinations: Seeing geometric patterns, vibrant colours, and distortions in shapes.
  • Altered perception of time and space.
  • Emotional and psychological effects, such as introspection and self-discovery.
  • Enhanced sensory perception.
  • Euphoria or mood swings.
  • Increased empathy and connection with others.

How to

Mescaline is a naturally occurring psychedelic alkaloid of the phenethylamine class, known for its hallucinogenic effects. It’s found in certain cacti species, such as Peyote (Lophophora williamsii), the San Pedro cactus (Echinopsis pachanoi), and the Peruvian Torch cactus (Echinopsis peruviana). There are several traditional and modern methods of administration:

  • Chewing the Cactus: The most traditional method involves directly chewing the flesh of the cactus. This can be quite bitter and difficult to digest for some people.
  • Making a Tea or Brew: Boiling the cactus pieces in water to make a tea is another common method. This can be easier to consume but still has a strong, bitter taste.
  • Dried and Ground into Powder: The cactus can be dried and ground into a powder, which can then be swallowed, encapsulated, or mixed with water.
  • Extracts: More modern methods include extracting it into a more concentrated form, which can be consumed in smaller, more controlled doses.
  • Edible Preparations: Some people incorporate mescaline-containing cacti into food items, although this is less common due to the taste and digestive challenges.
  • Smoking: While less common, it is possible to smoke it, but this requires a chemical extraction process to isolate the substance from the cactus material.

Can you mix it with other substances? Click here for a detailed chart of safe drug combinations.

Benefits & Risks

BenefitsSelf-discovery and introspection: Mescaline can lead to profound insights about oneself and the world, potentially aiding personal growth.
Spiritual and mystical experiences: Many users report deeply spiritual and transcendent encounters during their mescaline trips.
Creativity: Some individuals find that mescaline enhances their creative thinking and problem-solving abilities.
RisksPsychological distress: Mescaline can lead to challenging or frightening experiences, known as “bad trips.”
Risk of accidents: Impaired judgment and perception during the trip can lead to accidents or dangerous behavior.
Legal consequences: Mescaline is a controlled substance in many countries, and possession or use can result in legal trouble.
Long-term mental health effects: While there is no conclusive evidence, there is concern that regular use of psychedelics like mescaline could potentially have long-term effects on mental health.

Therapeutic Use

The substance has been explored for its therapeutic potential in the treatment of various mental health conditions, including depression, anxiety, and substance use disorders. Research on the therapeutic use of mescaline and other psychedelics is ongoing, with promising results in clinical trials.

Personal Growth

Mescaline, like other psychedelics, is sometimes used as a tool for personal growth and self-improvement. Users often report gaining new perspectives on their lives, relationships, and purpose, which can lead to personal development and positive life changes.


The legal status of mescaline varies by country and jurisdiction. In the United States, mescaline is classified as a Schedule I controlled substance, making it illegal to possess or distribute. However, some Native American tribes are allowed to use peyote for religious and ceremonial purposes. Other countries may have their own regulations regarding mescaline.

History & Stats

Mescaline has a rich history of use among indigenous peoples in the Americas, particularly in the southwestern United States and Mexico. It has been used for thousands of years in religious and shamanic rituals. In the 20th century, mescaline gained popularity in Western counterculture movements, such as the 1960s psychedelic revolution.

As for statistics, it’s challenging to provide precise data on mescaline use due to its illegal status in many places. However, the interest in mescaline and other psychedelics has been on the rise in recent years, leading to increased research and exploration of its potential.


There are various myths and misconceptions surrounding Mescaline, such as:

  • “it is the same as LSD or psilocybin“: While these substances share some similarities, they have distinct effects and come from different sources.
  • “it is always safe and pleasant”: Mescaline can lead to challenging experiences, and its effects are highly variable.
  • “it can permanently damage your brain“: There is limited evidence to suggest that moderate and infrequent use of mescaline is associated with long-term negative effects on the brain. More research is needed to draw firm conclusions.

It’s important to approach mescaline with caution and understand its effects and risks. Have you had an experience with mescaline and need support to integrate it? Or do you plan on having one and want the best setting possible? Book a session with one of our coaches.

Our Psychedelic Coaches Integrating Mescaline Experiences